Family-based Gene-by-environment Interaction Studies
نویسندگان
چکیده
منابع مشابه
Effects of the family environment: gene-environment interaction and passive gene-environment correlation.
The classical twin study provides a useful resource for testing hypotheses about how the family environment influences children's development, including how genes can influence sensitivity to environmental effects. However, existing statistical models do not account for the possibility that children can inherit exposure to family environments (i.e., passive gene-environment correlation). The au...
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The literature on candidate gene associations is full of reports that have not stood up to rigorous replication. This is the case both for straightforward main effects and for candidate gene-by-environment interactions (Duncan and Keller 2011). As a result, the psychiatric and behavior genetics literature has become confusing and it now seems likely that many of the published findings of the la...
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It is important to investigate whether genetic susceptibility variants exercise the same effects in populations that are differentially exposed to environmental risk factors. Here, we assess the power of four two-stage case-control design strategies for assessing multiplicative gene-environment (G-E) interactions or for assessing genetic or environmental effects in the presence of G-E interacti...
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It is a commonly held belief that most complex diseases (e.g., diabetes, asthma, cancer) are affected in part by interactions between genes and environmental factors. However, investigators conducting genome-wide association studies typically test for only the marginal effects of each genetic marker on disease. In this paper, the authors propose an efficient and easily implemented 2-step analys...
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BACKGROUND The search for interaction effects is common in epidemiological studies, but the power of such studies is a major concern. This is a practical issue as many future studies will wish to investigate potential gene-gene and gene-environment interactions and therefore need to be planned on the basis of appropriate sample size calculations. METHODS The underlying model considered in thi...
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ژورنال
عنوان ژورنال: Epidemiology
سال: 2011
ISSN: 1044-3983
DOI: 10.1097/ede.0b013e318212fec6